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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Immunohistochemical expression of VEGF in hepatocellular carcinoma and surrounding liver tissue Print E-mail
Written by Basa N., Cornianu M., Lazar E., Dema A., Taban S., Lazar D., Lazureanu C., Faur A., Tudor A., Mos L., Pribac G.C.   
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Article Title: Immunohistochemical expression of VEGF in hepatocellular carcinoma and surrounding liver tissue
Authors: Norina Basa 1, Marioara Cornianu 2, Elena Lazăr 2, Alis Dema 2, Sorina Tăban 2, Daniela Lazăr 3, Codruţa Lăzureanu 2, Alexandra Faur 2, A. Tudor 4, Liana Moş 5, George Ciprian Pribac 5
Affiliation: 1County Hospital; 2Department of Pathology; 3Gastroenterology Clinic;
4Biophysics Department, University of Medicine and Pharmacy “Victor Babeş” Timişoara
5”Vasile Goldiş” Western University of Arad
Abstract: Introduction: Angiogenesis is a fundamental process involved in malignant transformation and progression of cancer, in tumor growth and metastasis. VEGF plays an essential role in the angiogenesis of hepatocellular carcinoma (HCC). Method: We evaluated VEGF expression in 16 resected HCCs and in the surrounding liver tissue using the IHC staining method and monoclonal antibody anti-VEGF, clone VG1. The results were statistically analyzed using the Epi Info 6.04 program; we considered as significant the value < 0.05. Results: Positive VEGF expression was observed in 14 (87.7%) of the 16 patients with HCC and in 62.5% of the surrounding liver tissue (cirrhotic or non-cirrhotic), without significant differences between HCC and non-Tumor liver (0.11). Capsular infiltration (p=0.242), vascular invasion (p=0.383) and intrahepatic metastases (p=0.13) were observed more frequently in patients with positive VEGF expression. Conclusions: VEGF expression was higher in HCC than in cirrhotic nodules; our results suggest that VEGF can play an important role in the angiogenesis and prognosis of HCC, as well as in the angiogenesis of liver cirrhosis.
Keywords: angiogenesis, VEGF, HCC, surrounding liver tissue
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