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CNCSIS B+ (code 820) since 2007

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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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The effect of ischemic preconditioning upon molecular and ultrastructural aspects of rat myocardium Print E-mail
Written by Revnic C.R., Ginghina C., Caloianu M., Botea S., Revnic F.   
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Article Title: The effect of ischemic preconditioning upon molecular and ultrastructural aspects of rat myocardium
Authors: Cristian Romeo Revnic1*, Carmen Ginghina2, Maria Caloianu3, Simona Botea4, Floarea Revnic5
Affiliation: 1 University of Medicine and Pharmacy ”Carol Davila” Bucharest, Romania
2 C.C. Iliescu Institute, Department of Cardiology Bucharest, Romania
3 National Institute for Research and Development in Biological Sciences, Department of Electron Microscopy, Bucharest, Romania
4 “Victor Babes” Institute, Department of Molecular Pathology, Bucharest, Romania
5 National Institute of Geriatrics and Gerontology, Department of Cell and Molecular Biology, Bucharest, Romania
Abstract: The aim of our study was to characterise the Langendorff model of rat heart investigating different durations of ischemia and reperfusion and ischemic precondition protocol (IPC) on myocardial ischemia reperfusion injury to test the potential clinical relevance of ischemic preconditioning (IP) phenomenon on infarct size, to assess genomic DNA integrity and histological and ultrastructural changes in heart muscle. Our results have shown that as ischemia and reperfusion time is extended the level of infarction is also increased. We concluded that 20 minutes stabilisation and 45 minutes ischemia followed by 30 minutes reperfusion seems to provide a compliant platform to study ischemia reperfusion injury. Protection using (ICP) was induced by 2 cycles 5` ischemia and 5` reperfusion prior lo lethal ischemia reperfusion protocols. The reduction in infarct size in IP hearts pointed out that inhibition of apoptosis is one of the mechanisms which participate in electing the increased resistance to ischemia. The potential clinical relevance of IP on ischemia-reperfusion injury is the object of clinical research to find new methods of cardioprotection in humans.
Keywords: ischemic preconditioning, apoptosis, necrosis, ischemia, reperfusion
References: Arun K. Singhal1,, J. David Symons2, *, Sihem Boudina3, Bharat Jaishy3 and Yan-Ting E. Shiu Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury, Vascular Disease Prevention, 2010, 7, 1-14
Bolli R, Becker L, Gross G, Mentzer R Jr, Balshaw D, Lathrop DA. Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res 2004; 95:125-34.
Conrad GL, Rau EE, Shine KL.Creatine kinase release, potassium-42 content, and mechanical performance in anoxic rabbit myocardium. J Clin Invest 1979;64:155–61.
Cohen,M.V. and Downey,J.M. (2008). Adenosine: trigger and mediator of cardioprotection. Basic Res Cardiol. 103, 203-215.
Dauterman K. and Topol,E. (2002).Optimal treatment and current situation in reperfusion after thrombolysis for acute myocardial infarction. Ann. Med. 34, 514-522.
Derek M. Yellon, D.Sc., and Derek J. Hausenloy, Ph.Myocardial Reperfusion Injury. N Engl J Med 2007;357:1121-35.
Ferdinandy P., Schultz R., Baxter G.F. (2007) Interrelations of cardiovascular risc factors with myocardial ischemia/reperfusion injury preconditioning and postconditioning. Pharmacol Rev 59 418-458.
Gross,E.R., Hsu,A.K., and Gross,G.J. (2008). Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a. Am J Physiol HeartCirc Physiol 294, H1497-H1500.
Hausenloy,D.J., Tsang,A., and Yellon,D.M. (2005). The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc. Med. 15, 69-75.
Klein, H.H., Puschmann,S., Schaper,J., and Schaper,W. (1981). The mechanism of the tetrazolium reaction in identifying experimental myocardial infarction. Virchows Archiv A Pathological Anatomy and Histology 393, 287-297.
Murry,C.E., Jennings,R.B., and Reimer,K.A. (1986). Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74, 1124-1136.
Revnic C.R., Popa C., Nica A.S., Ginghina C., Revnic F. The evaluation of carotid stenosis as risk factor for stroke in hypertensive diabetic and nondiabetic patients. Archives of gerontology& geriatrics.Suppl.(2007)331-334 ELSEVIER 0167-4943/S
Revnic C.R., Ginghina C., Nica A., Revnic F., Botea S., Biophysical studies of erythrocite membrane permeability in patients with cardiovascular pathology, New Horizons in Coronary artery Disease Proceedings of the 7th International Congress on Coronary Artery Disease Venice 7-10 Oct.2007, Ed.Medimond pp.37-41
Revnic C.R., Popa C., .Nica A.S., Ginghina C., Revnic F. Comparative echo-doppler study in diabetic and non diabetic patients with carotid macroangiopahy, Archives of gerontology&geriatrics: Suppl.(2007)327-330-342 ELSEVIER 0167-49435.
Revnic C.R., Nica A.S., Revnic F. The impact of physical training on endocrine modulation, muscle physiology and sexual functions in elderly men. Archives of gerontology & geriatrics : Suppl. (2007) 339-342 ELSEVIER 0167-4943/S
Revnic C.R., Nica A., Ginghina C., Revnic F., Botea S. Evaluation of Cytotoxic activity of polymorphonuclear cells from patients with acute coronary syndromes pathologies. New Horizons in: Coronary Artery Disease, Proceedings of 7th International Congress on CAD, Venice, oct.7-10,2007,pp59-62
Revnic C.R., Nica A., Ginghina C., Revnic F., Botea S. Evaluation of apoptosis in lymphocites from patients with acute coronary syndromes New Horizons in :Coronary Artery Disease ,Proceedings of 7th International Congress on CAD,Venice,oct.7-10,2007,pp53-57
Revnic C.R.,Ginghina C.,Nica A., Revnic F.The impact of ischemia/reperfusion upon ionic transport (Na,K) and functional parameters in rat heart From: New approaches in coronary artery disease, Proceedings of 8th International Congress on Coronary Artery Disease,Oct.11-14, 2009, Prague, Czech Republic, Ed.Medimond, International Proceedings, pp.283-286
Revnic C.R., Ginghina C., Georgescu M.,Botea S., Revnic F.,Evaluation of physiological parameters of hypertensive rat heart during ischemia-reperfusion. Annas of National Cell Biology Society, vol X, 2005, RISOPRINT,ISSN 1583-6258
Revnic F.,Revnic C.R., Botea S. The effect of oxidative stress of ischemia-reperfusion upon physiological parameters of rat heart of different ages. Annas of National Cell Biology Society,vol. IX,nr.1 Cap.I Risoprint 2004
Revnic F .,. Caloianu M.,Voiculescu B., Iordachel R., Revnic C.R. Functional and ultrastructural aspects of aging in human quadratus skeletal muscle. Rom.Journal of Biol.Sci. vol.IV, Nr.1-4 pag65-70, 2002.
*Correspondence: Cristian Romeo Revnic,University of Medicine and Pharmacy ”Carol Davila” Bucharest, Romania,
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