SCImago Journal & Country Rank

Ranking and Indexing

Rank:
Index Copernicus Value (2010): 5.45
CNCSIS B+ (code 820) since 2007

International Databases:
SCOPUS since 2009
EBSCO Academic Search Complete since 2008
Index Copernicus Journals Master List since 2009
Directory of Open Access Journals (DOAJ) since 2008
ProQuest
Genamics JournalSeek since 18/2008

International Catalogues:
Oxford University's Library since 2003

Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

Who's Online

We have 259 guests online

Index Databases

The occurrence and distribution of adrenomedullin (AM) in the endocrine pancreas of several... Print E-mail
Written by Trandaburu I., Trandaburu T.   
Read full article
Article Title: The occurrence and distribution of adrenomedullin (AM) in the endocrine pancreas of several poikilotherm vertebrates: An immunohistochemical study
Authors: Ioana Trandaburu1, Tiberiu Trandaburu2
Affiliation: 1 Centre of Cytobiology, Institute of Biology, Bucharest, Romania
2 University of Pitesti, Romania, Faculty of Sciences, Laboratory of Histology and Embryology
Abstract: The pancreas of six amphibian and two turtle species was investigated for the immunohistochemical detection of the adrenomedullin (AM). The study revealed various degrees of labelling for this neuropeptide depending on the species and endocrine cell type differences, even within the same endocrine cell population. The immunolabelled neural structures represented by nerve fibbers and possible ganglionic perikarya or endocrine cells showed peri-insular localizations in the species Hyla arborea, whereas in the genus Rana were distributed throughout the organ. The AM distribution related to the main insular hormones (PP, SOM, INS, GLUC) was investigated on adjacent serial sections in the species Rana esculenta. The investigations have showed that only part of cells labelled for AM contained also pancreatic hormones in the following order: GLUC > SOM > PP > INS. The above findings and their functional significances supporting the good conservation of AM during phylogeny are discussed in connection with the results previously reported in mammals and other poikilotherm vertebrates.
Keywords: adrenomedullin, AM, amphibians, turtles, pancreas, immunohistochemistry
References: Jougasaki M, Wei CM, Heublein DM, Sandberg SM, Burnett JC. Immunohistochemical localization of adrenomedullin in canine heart and aorta. Peptides. 1995; 16: 773-75.
Olaru L. Contrbutions regarding the cytoarhitecture and immunohistochemistry of the diffuse neuroendocrine gastro-entero-pancreatic (GEP) system in amphibians. (doctoral thesis), 2005.
Kitamura K, Kanagawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys Res Commun. 1993; 192: 533-60.
Washimine H, Asada Y, Kitamura K, Ichiki Y, Hara S, Yamamoto Y, Kanagawa K, Sumiyoshi A, Eto T. Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissues. Histochemistry. 1995; 103: 251-54.
Ebara T, Miura K, Okumura M, Matsuura T, Kim S, Yukimura T, Iwao H. Effects of adrenomedullin on renal hemodynamic and functions in dogs. Eur J Pharmacol. 1994; 263: 69-73.
Allen MA, Ferguson AY. In vitro recordings from area postrema neurons demonstrate responsiveness to adrenomedullin. Am J Physiol. 1996; R 920-R 925.
Nuki C, Kawasaki H, Kitamura K, Takenaga M, Kanagawa K, Eto T, Wada A. Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun. 1993; 196: 245-51.
Nossaman DB, Feng CJ, Cheng DY, Dewitt BJ, Coy DH, Murphy WA, Kadowitz PJ. Comparative effects of adrenomedullin, an adrenomedullin analogue, and CGRP in the pulmonary vascular bed of the cat and rat. Life Sci. 1995; 56: 63-6.
Miller MJ, Martinez A, Unsworth E, Thiele CJ, Moody TW, Cuttitta F. Adrenomedullin: expression in human tumor cell lines and its potential role as an autocrine growth factor. J Biol Chem. 1996; 271: 23345-351.
Kaspas S, Catt KJ, Clarck JL. Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J Biol Chem. 1995; 270: 24344-347.
Wimalawansa SJ. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev Neurobiol. 1977; 11: 167-239.
Ishiyama Y, Kitamura K, Ichiki Y, Nakamura S, Kida O, Kanagawa K, Eto T. Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats. Eur J Pharmacol. 1933; 241: 271-73.
Kanazawa H, Kurihara N, Hirota K, Kudoh S, Kawaguchi T, Takeda T. Adrenomedullin, a novel discovered hypotensive peptide, is a potent bronchodilator. Biochem Biophys Res Commun. 1994; 205: 251-54.
Walsh TJ, Martinez A, Peter J, Unsworth EJ, Cuttitta F. Antimicrobial activity of adrenomedullin and its gene-related peptide. J Biol Chem. 1998; 273: 3421-428.
Samson WK, Murphy T, Schell DA. A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release. Endocrinology. 1995; 136: 2349-352.
Mazzocchi G, Musajo F, Neri G, Gottardo G, Nussdorfer G. Adrenomedullin stimulates steroid secretion by the isolated perfused rat adrenal gland in situ: comparison with calcitonin gene-related peptide effects. Peptides. 1996; 17: 852-57.
Mulder H, Ahrén B, Karlsson S, Sundler F. Adrenomedullin: localization in the gastrointestinal tract and effect on insulin secretion. Regul Pept. 1996; 62: 107-12.
Martinez A, Weaver C, Lopez L, Bhathena SJ, Elsasser TH, Miller MJ, Moody TW, Unsworth EJ, Cuttitta F. Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Endocrinology. 1996; 137: 2626-632.
Martinez A, Cuttitta F, Teitelman G. Expression pattern for adrenomedullin during pancreatic development in the rat reveals a common precursor with other endocrine cell types. Cell Tiss Res. 1998; 293: 95-100.
Pio R, Martinez A, Cuttitta F. Cancer and diabetes: two pathological conditions in which adrenomedullin may be involved. Peptides. 2001; 22: 1719-729.
Asada Y, Seiichiro H, Marutsuka K, Kitamura K, Fuji T, Sakata J, Sato J, Kisanuki A, Eto T, Sumiyoshi A. A novel distribution of adrenomedullin immunoreactive cells in human tissues. Cell Tiss Res. 1999; 292: 45-58.
Lopez J, Cuesta N. Adrenomedullin as a pancreatic hormone.Microsc Res Techn. 2002; 57: 61-75.
Marutsuka K, Hatekayama K, Sato Y, Yamashita A, Sumiyoshi A, Asada Y. Immunohistological localization and possible functions of adrenomedullin. Hypertens Res. 2003; 26: 33-40.
Satoh F, Takahashi K, Murakami O, Totsune K, Sone M, Ohneda M, Abe K, Miura J, Hayashi Y, Sasano H, Mouri T. Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. J Clin Endocrinol Metabol. 1995; 80: 1750-752.
Trandaburu I, Olaru L, Trandaburu T. The occurrence and distribution of adrenomedullin immunoreactivity in the gut of amphibians and reptiles. Proc Inst Biol. 2000; 3: 471-78.
Gonzales A, Marin O, Sanchez-Camacho C, Pena JJ, Zudaire JJ, Martinez A, Cuttitta F, Munoz M. Localization of adrenomedullin-like immunoreactivity in the hypothalamo-hypophysial system of amphibians. Neurosci Lett. 1998; 242: 13-6.
Lopez J, Cuesta N, Cuttitta F, Martinez A. Adrenomedullin in nonmammalian vertebrate pancreas: an immunocytochemical study. Gen Comp Endocrinol. 1999; 3: 309-22.
Collantes M, Bodegas ME, Sesma MP, Villaro AC. Distribution of adrenomedullin and proadrenomedullin N-terminal 20 peptide immunoreactivity in the pituitary gland of the frog Rana perezi. Gen Comp Endocrinol. 2003; 1: 50-60.
Kato F, Kitamura K, Niina H, Yomamoto R, Washimine H, Kanagawa K, Yamamoto Y, Kobayashi H, Eto T, Wada A. Proadrenomedullin N-terminal 20 peptide (PAMP), an endogenous anticholinergic peptide: its exocytotic secretion and inhibition of catecholamine secretion in adrenal medulla. J Neurochem. 1995; 64: 459-61.
Sakata J, Asada Y, Shimokubo T, Kitani H, Inatsu H, Kitamura K, Kanagawa K, Matsuo H, Sumiyoshi A, Eto T. Adrenomedullin in the gastrointestinal tract. Distribution and gene expression in rat and augmented gastric adrenomedullin after fasting. J Gastroenterol. 1998; 33: 828-34.
Ishizaka Y, Ishizaka Y, Tanaka M, Kitamura K, Kanagawa K, Minamino N, Matsuo H, Eto T. Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells. Biochem Biophys Res Commun. 1994; 200: 642-46.
Sternberger LA. Immunocytochemistry. Prentice Hall Englewood Cliffs, UK. 1974.
Ogoshi M, Inoue K, Takei Y. Identification of a novel adrenomedullin gene family in teleost fish. Biochem Biophys ResCommun. 2003; 311: 1072-74.
Martinez A, Unsworth EJ, Cuttitta F. Adrenomedullin-like immunoreactivity in the nervous system of the starfish Marthasterias glacialis. Cell Tissue Res. 1996; 283: 169-72.
Montuenga LM, Martinez A, Miller MJ, Unsworth EJ, Cuttitta F. Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine models of action. Endocrinology. 1996; 138: 440-51.
Kitani M, Sakata J, Asada Y, Kitamura K, Eto T. Distribution and expression of adrenomedullin in human gastrointestinal tissue. Ann Clin Biochem. 1998; 35: 643-48.
*Correspondence: Ioana Trandaburu, Institute of Biology, Spl. Independenţei 296, 060031, Bucharest, e-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it ; This e-mail address is being protected from spambots. You need JavaScript enabled to view it