SCImago Journal & Country Rank

Ranking and Indexing

Index Copernicus Value (2017): 105.85
CNCSIS B+ (code 820) since 2007

International Databases:
SCOPUS since 2009
EBSCO Academic Search Complete since 2008
Index Copernicus Journals Master List since 2009
Directory of Open Access Journals (DOAJ) since 2008
Genamics JournalSeek since 18/2008

International Catalogues:
Oxford University's Library since 2003

Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

Who's Online

We have 81 guests online

Index Databases

The action of some antioxidant compounds with Flavonolignanes (Silimarin and Legalon) on the rat liver, intoxicated with N-nitrosodimethylamine (NDMA) Print E-mail

Authors: Ioana ROMAN1*, Mircea A. RUSU1, Constantin PUICĂ1, Maria BORŞA1

Affiliation: 1 Animal Physiology Laboratory, Institute of Biological Research, Cluj-Napoca


Read full article


ABSTRACT. The effects of drugs (compounds) with flavonolignanes (Silimarin and Legalon) on the liver of male Wistar rats, intoxicated with N- nitrosodimethylamine (NDMA) (produced by the administration of aminopyrine+Na nitrite), during 30 days, were investigated.

Biochemical parameters, including serum transaminase activity (GPT and GOT), the glycogen content; histoenzymological (lactate dehidrogenase, succinat-dehidrogenase, glutamate-dehidrogenase, steroid dehidrogenase, cytochromoxidase, Mg-dependent adenosine triphosphatase, glucose-6-phosphatase): histochemical (Sudan black for lipids) and histological examination (haematoxilin-eosine staining) of the liver were studied. Administrations of aminopyrine + Na nitrite produce in stomach of rat the N-nitrosodimethylamine. This has a very complex and toxic actions in rats’ liver: decreases of survival, hepatocytolisis, necrosis, steatosis, proliferation of collagen, decreases of glycogen level, reduction of enzymatic activities, like cirrhotic modifications.

The utilization of Silimarin and Legalon has some positive effects such as: a smaller mortality, decreases of histological injury, reduction of hepatocytolisis, necrosis, steatosis and collagen proliferation; enzymatic activity is more increased than intoxicated rats. The rich content of Silimarin and Legalon in flavonolignanes, antioxidants, may be the cause of these positive effects.


Keywords: N-nitrosodimethylamine, intoxicated, liver rats, Silimarin, Legalon