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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Histochemical and biochemical analysis regarding the protective effects of some bioactive compounds in the brain of rabbit fetuses prenatally exposed to some excitotoxins Print E-mail

Authors: Constantin PUICĂ1*, Mircea RUSU1, Mihai CRISTESCU2, Ioana ROMAN1, Maria BORSA1

Affiliation: 1 Institute of Biological Research Cluj-Napoca, Romania; 2 University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania


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ABSTRACT. Administration of L-monosodium glutamate (MSG), L-aspartate (ASP) and L-cysteine (CYS), in the organogenesis period (6-18 days) of gestation in rabbits induced a reduction of the nuclear DNA and RNA fluorescence in all neuronal brain populations, and a significant decrease of DNA and protein quantity in total brain homogenate, comparative to control group Administration of MSG, ASP and CYS associed with a vitamin-mineral bioactive complex in the same period of gestation shows a moderate diminution of the DNA and RNA fluorescence, in all neuronal brain structures, and a moderate decrease of DNA and protein quantity comparative to C group.


Keywords: excitotoxins, bioactive complex, gestation, rabbits, DNA, RNA fluorescence, DNA, protein quantity