SCImago Journal & Country Rank

Ranking and Indexing

Index Copernicus Value (2017): 105.85
CNCSIS B+ (code 820) since 2007

International Databases:
SCOPUS since 2009
EBSCO Academic Search Complete since 2008
Index Copernicus Journals Master List since 2009
Directory of Open Access Journals (DOAJ) since 2008
Genamics JournalSeek since 18/2008

International Catalogues:
Oxford University's Library since 2003

Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

Who's Online

We have 16 guests online

Index Databases

Ultrastructural aspects concerning the hypothalamus-pituitary complex reactivity following chronic administration of Aspartame in juvenile rats Print E-mail

Authors: Constantin PUICĂ1*, Constantin CRĂCIUN2, Mircea RUSU1, Mihai CRISTESCU3, Maria BORSA1, Ioana ROMAN1

Affiliation: 1 Biological Research Institute, Cluj-Napoca; 2 Babes-Bolyai University, Electron Microscopy Center, Cluj-Napoca; 3 University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca


Read full article


ABSTRACT. The aim of this study was to determine the effects of chronic ingestion for a period of 30 days, of Aspartame (ASP) on neuronal and pituitairies ultrastructure in juvenile rats. The neuronal ultrastructure of hypothalamic ventraly-medialy area (VMH), CA1 hippocampic area and of anterior pituitary GH, LH-FSH cells have been investigated by electron microscopy. Administration of 2 mg/kg b.w. of ASP induced some alteration of all neuronal ultrastructure in lesioned regions of hippocampus and hypothalamus. Degenerative aspects of all cellular constituents which are typical features for apoptosis were observed. GH cells in A1 group are polymorphic in regards to the shape and structure of both the nuclei and cellular organelles. There are many intense vacuolisations in the cytoplasm, both of the endoplasmic reticulum and the mitochondria. The pituitary LH-FSH cells seemed to have an altered structure, and they have few secretion granules.


Keywords: ultrastructural, hypothalamus, pituitary, complex, Aspartame, juvenile rats, rabbits