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CNCSIS B+ (code 820) since 2007

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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Preliminary study, by flow cytometric parameters and apoptotic markers, of mitochondrial disfunction in leukemia cells Print E-mail

Authors: Annamaria PALLAG1, Ladislau RITLI1, Aurel ARDELEAN2, Ildiko SZABO1, Simona BUNGĂU1

Affiliation: 1 Faculty of Medicine and Pharmacy, University, Oradea, 2 ”Vasile Goldiş” Western University, Arad

 

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ABSTRACT. The main purpose of the antineoplastic treatment is to induce apoptosis in the malignant cells. Apoptosis or programmed cell death is a process in which the deliberate degradation of the cell from the inside takes place, with the active selection of some genes and the failure of others, with the participation of the mitochondria for the propagation of the apoptotic signal, with changes in the phospholipid composition of the cell membrane, with the perturbation and alteration of the cell metabolism. The phases of apoptosis can be detected by flow cytometry. This way the changes in the phospholipid composition of the cell membrane can be determined, when phosphatidylserine (PS), usually on the inner side of the cell membrane, it is displayed on the surface. The aim of the present study is a preliminary analysis of the involvement of the mitochondria, as a major source of ROS in the cell, in the apoptotic process induced by the antineoplastic medication.

 

Keywords: apoptosis, leukemia, flow cytometer